Version 5.4
Homo sapiens Gene: VAMP8
Summary
InnateDB Gene IDBG-59222.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAMP8
Gene Name vesicle-associated membrane protein 8
Synonyms EDB; VAMP-8
Species Homo sapiens
Ensembl Gene ENSG00000118640
Encoded Proteins
IDBP-59224
vesicle-associated membrane protein 8 (endobrevin)
IDBP-295379
vesicle-associated membrane protein 8 (endobrevin)
IDBP-381622
vesicle-associated membrane protein 8 (endobrevin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85561562-85582031
Strand Forward strand
Band p11.2
Transcripts
ENST00000263864 ENSP00000263864
ENST00000409760 ENSP00000387094
ENST00000432071 ENSP00000407984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0019905 syntaxin binding
Biological Process
GO:0000046 autophagic vacuole fusion
GO:0006461 protein complex assembly
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006906 vesicle fusion
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030100 regulation of endocytosis
GO:0035493 SNARE complex assembly
GO:0046718 viral entry into host cell
GO:0061024 membrane organization
GO:0061025 membrane fusion
Cellular Component
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030141 secretory granule
GO:0030667 secretory granule membrane
GO:0031201 SNARE complex
GO:0031902 late endosome membrane
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050732
View Gene Order
ENSBTAG00000023997
Not yet available
Pathways
NETPATH
REACTOME
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003761
HUGO
OMIM
CCDS CCDS1979
HPRD 04415
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca