InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAMP8

Summary

InnateDB Protein

IDBP-59224.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP8

Protein Name

vesicle-associated membrane protein 8 (endobrevin)

Synonyms

EDB; VAMP-8;

Species

Homo sapiens

Ensembl Protein

ENSP00000263864

InnateDB Gene

IDBG-59222 (VAMP8)

Protein Structure

UniProt Annotation

Function

SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. {ECO:0000269PubMed:12130530, ECO:0000269PubMed:23217709}.

Subcellular Localization

Lysosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Platelets.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0000046	autophagic vacuole fusion
GO:0006461	protein complex assembly
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006906	vesicle fusion
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030100	regulation of endocytosis
GO:0035493	SNARE complex assembly
GO:0046718	viral entry into host cell
GO:0061024	membrane organization
GO:0061025	membrane fusion

Cellular Component

GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030141	secretory granule
GO:0030667	secretory granule membrane
GO:0031201	SNARE complex
GO:0031902	late endosome membrane
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome