Version 5.4
Homo sapiens Gene: GRK7
Summary
InnateDB Gene IDBG-59228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRK7
Gene Name G protein-coupled receptor kinase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114124
Encoded Proteins
IDBP-59230
G protein-coupled receptor kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:141778148-141818490
Strand Forward strand
Band q23
Transcripts
ENST00000264952 ENSP00000264952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0050254 rhodopsin kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa04744
Phototransduction pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
cone_pathway
Visual signal transduction: Cones
Cross-References
SwissProt Q8WTQ7
TrEMBL
UniProt Splice Variant
Entrez Gene 131890
UniGene Hs.680654
RefSeq NM_139209
HUGO HGNC:17031
OMIM 606987
CCDS CCDS3120
HPRD
IMGT
EMBL AC112504 AF282269 AF439409
GenPept AAL33880 AAL48216
RNA Seq Atlas 131890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca