InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRK7

Summary

InnateDB Protein

IDBP-59230.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRK7

Protein Name

G protein-coupled receptor kinase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264952

InnateDB Gene

IDBG-59228 (GRK7)

Protein Structure

UniProt Annotation

Function

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). {ECO:0000269PubMed:15946941}.

Subcellular Localization

Membrane; Lipid-anchor.

Disease Associations

Tissue Specificity

Retinal cones, outer and inner segments. {ECO:0000269PubMed:11754336, ECO:0000269PubMed:18803695}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050254	rhodopsin kinase activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007601	visual perception
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0046777	protein autophosphorylation

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000239 GPCR kinase
IPR000342 Regulator of G protein signalling domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016137 Regulator of G protein signalling superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00615
PF00069
PF07714

PRINTS

PR00717
PR01301
PR00109

PIRSF

SMART

SM00133
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt