Version 5.4
Homo sapiens Gene: GNLY
Summary
InnateDB Gene IDBG-59481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNLY
Gene Name granulysin
Synonyms 519; D2S69E; LAG-2; LAG2; NKG5; TLA519
Species Homo sapiens
Ensembl Gene ENSG00000115523
Encoded Proteins
IDBP-59483
granulysin
IDBP-295366
granulysin
IDBP-586527
granulysin
IDBP-600524
granulysin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85685175-85698854
Strand Forward strand
Band p11.2
Transcripts
ENST00000263863 ENSP00000263863
ENST00000409696 ENSP00000387116
ENST00000488945
ENST00000489214
ENST00000482900
ENST00000464298
ENST00000470974
ENST00000489980
ENST00000491234
ENST00000524600 ENSP00000436423
ENST00000533041
ENST00000534351
ENST00000531685
ENST00000526018 ENSP00000434467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006968 cellular defense response
GO:0031640 killing of cells of other organism
GO:0042742 defense response to bacterium
GO:0050832 defense response to fungus
Cellular Component
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P22749
TrEMBL
UniProt Splice Variant
Entrez Gene 10578
UniGene
RefSeq NM_012483 NM_006433 XM_005264086
HUGO HGNC:4414
OMIM 188855
CCDS CCDS46354 CCDS1984
HPRD 01788
IMGT
EMBL BC023576 CR541859 M85276 X05044 X54101
GenPept AAA59935 AAH23576 CAA28715 CAA38035 CAG46657
RNA Seq Atlas 10578

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca