Version 5.4
Homo sapiens Protein: GNLY
Summary
InnateDB Protein IDBP-59483.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNLY
Protein Name granulysin
Synonyms 519; D2S69E; LAG-2; LAG2; NKG5; TLA519;
Species Homo sapiens
Ensembl Protein ENSP00000263863
InnateDB Gene IDBG-59481 (GNLY)
Protein Structure
UniProt Annotation
Function Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
Subcellular Localization Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
Disease Associations
Tissue Specificity Expressed in natural killer and T-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006968 cellular defense response
GO:0031640 killing of cells of other organism
GO:0042742 defense response to bacterium
GO:0050832 defense response to fungus
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR008138 Saposin-like type B, 2
IPR008139 Saposin B
IPR011001 Saposin-like
PFAM PF03489
PRINTS
PIRSF
SMART SM00741
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22749
PhosphoSite PhosphoSite-P22749
TrEMBL
UniProt Splice Variant
Entrez Gene 10578
UniGene
RefSeq NP_006424
HUGO HGNC:4414
OMIM 188855
CCDS CCDS1984
HPRD 01788
IMGT
EMBL BC023576 CR541859 M85276 X05044 X54101
GenPept AAA59935 AAH23576 CAA28715 CAA38035 CAG46657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca