Version 5.4
Homo sapiens Gene: ST3GAL5
Summary
InnateDB Gene IDBG-59513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST3GAL5
Gene Name ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms SATI; SIAT9; SIATGM3S; ST3GalV
Species Homo sapiens
Ensembl Gene ENSG00000115525
Encoded Proteins
IDBP-59515
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
IDBP-59517
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
IDBP-242874
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
IDBP-242878
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
IDBP-381817
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
IDBP-381822
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85839144-85889014
Strand Reverse strand
Band p11.2
Transcripts
ENST00000377332 ENSP00000366549
ENST00000306262 ENSP00000306247
ENST00000393808 ENSP00000377397
ENST00000393805 ENSP00000377394
ENST00000455892 ENSP00000401375
ENST00000433665 ENSP00000408635
ENST00000461206
ENST00000487896
ENST00000473122
ENST00000461892
ENST00000461199
ENST00000484728
ENST00000490946
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity
GO:0008373 sialyltransferase activity
GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0006688 glycosphingolipid biosynthetic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056091
View Gene Order
ENSBTAG00000011601
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00604
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.736775
RefSeq NM_001042437 NM_003896
HUGO
OMIM
CCDS CCDS1986 CCDS42705
HPRD 05098
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca