InnateDB Protein
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IDBP-242878.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ST3GAL5
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Protein Name
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ST3 beta-galactoside alpha-2,3-sialyltransferase 5
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Synonyms
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SATI; SIAT9; SIATGM3S; ST3GalV;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377394
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InnateDB Gene
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IDBG-59513 (ST3GAL5)
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Protein Structure
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Function |
Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). {ECO:0000269PubMed:16934889}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
Amish infantile epilepsy syndrome (AIES) [MIM:609056]: An autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness. {ECO:0000269PubMed:15502825}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004513
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neolactotetraosylceramide alpha-2,3-sialyltransferase activity
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GO:0008373
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sialyltransferase activity
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GO:0047291
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lactosylceramide alpha-2,3-sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR012163
Sialyltransferase
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PFAM |
PF00777
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PRINTS |
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PIRSF |
PIRSF005557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UNP4
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PhosphoSite |
PhosphoSite-Q9UNP4
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TrEMBL |
C9JYS9
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UniProt Splice Variant |
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Entrez Gene |
8869
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UniGene |
Hs.736775
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RefSeq |
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HUGO |
HGNC:10872
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OMIM |
604402
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CCDS |
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HPRD |
05098
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IMGT |
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EMBL |
AB018356
AC105053
AF105026
AF119415
AK001340
AY152815
AY359105
BC065936
CH471053
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GenPept |
AAD14634
AAF66146
AAH65936
AAO16866
AAQ89463
AAY24147
BAA33950
BAG50894
EAW99475
EAW99479
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