Version 5.4
Homo sapiens Gene: TOM1L1
Summary
InnateDB Gene IDBG-59902.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOM1L1
Gene Name target of myb1 (chicken)-like 1
Synonyms OK/KNS-CL.3; SRCASM
Species Homo sapiens
Ensembl Gene ENSG00000141198
Encoded Proteins
IDBP-59904
target of myb1 (chicken)-like 1
IDBP-382002
target of myb1 (chicken)-like 1
IDBP-603923
target of myb1 (chicken)-like 1
IDBP-764518
IDBP-759489
IDBP-763400
IDBP-764787
IDBP-764799
IDBP-763907
IDBP-759211
IDBP-758878
IDBP-758428
IDBP-761479
IDBP-762703
IDBP-757850
IDBP-758415
IDBP-759481
IDBP-760529
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:54899387-54961956
Strand Forward strand
Band q22
Transcripts
ENST00000348161 ENSP00000343901
ENST00000445275 ENSP00000408958
ENST00000536554 ENSP00000443099
ENST00000572298 ENSP00000459003
ENST00000574318 ENSP00000467227
ENST00000572405 ENSP00000460721
ENST00000573607 ENSP00000461396
ENST00000570623
ENST00000572158 ENSP00000461284
ENST00000572360 ENSP00000460565
ENST00000570371 ENSP00000458553
ENST00000570499 ENSP00000461215
ENST00000576932 ENSP00000461876
ENST00000574653
ENST00000572905
ENST00000571319 ENSP00000458219
ENST00000575333 ENSP00000458918
ENST00000570965 ENSP00000459079
ENST00000575882 ENSP00000460823
ENST00000570977
ENST00000574744
ENST00000575909 ENSP00000460213
ENST00000572576 ENSP00000458809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 70 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030276 clathrin binding
GO:0030295 protein kinase activator activity
GO:0043130 ubiquitin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045839 negative regulation of mitosis
GO:0045860 positive regulation of protein kinase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020541
View Gene Order
ENSBTAG00000007013
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B7Z9E2 I3L1Q1
UniProt Splice Variant
Entrez Gene 10040
UniGene Hs.153504 Hs.579318 Hs.733867
RefSeq NM_005486 XM_005256914 XM_005256915 XM_006721630
HUGO HGNC:11983
OMIM 604701
CCDS CCDS11582
HPRD 05266
IMGT
EMBL AC007485 AC090824 AK315907
GenPept BAH14278
RNA Seq Atlas 10040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca