InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOM1L1

Summary

InnateDB Protein

IDBP-758415.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOM1L1

Protein Name

Synonyms

OK/KNS-CL.3; SRCASM;

Species

Homo sapiens

Ensembl Protein

ENSP00000460823

InnateDB Gene

IDBG-59902 (TOM1L1)

Protein Structure

UniProt Annotation

Function

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack. Endosome membrane {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=A small proportion is membrane-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0030276	clathrin binding
GO:0030295	protein kinase activator activity
GO:0043130	ubiquitin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0031954	positive regulation of protein autophosphorylation
GO:0032147	activation of protein kinase activity
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045839	negative regulation of mitosis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005795	Golgi stack
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0070062	extracellular vesicular exosome