Version 5.4
Homo sapiens Gene: PCBP3
Summary
InnateDB Gene IDBG-6002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCBP3
Gene Name poly(rC) binding protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183570
Encoded Proteins
IDBP-228528
poly(rC) binding protein 3
IDBP-228530
poly(rC) binding protein 3
IDBP-228532
poly(rC) binding protein 3
IDBP-228534
poly(rC) binding protein 3
IDBP-228536
poly(rC) binding protein 3
IDBP-228538
poly(rC) binding protein 3
IDBP-371230
poly(rC) binding protein 3
IDBP-592141
poly(rC) binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:45643694-45942454
Strand Forward strand
Band q22.3
Transcripts
ENST00000400314 ENSP00000383168
ENST00000400310 ENSP00000383165
ENST00000400309 ENSP00000383164
ENST00000400308 ENSP00000383163
ENST00000400305 ENSP00000383160
ENST00000400304 ENSP00000383159
ENST00000449640 ENSP00000401198
ENST00000423045
ENST00000465077
ENST00000472191
ENST00000481302
ENST00000498121
ENST00000468429
ENST00000475402
ENST00000549265 ENSP00000448986
ENST00000594320
ENST00000593338
ENST00000594149
ENST00000609985
ENST00000610200
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0016071 mRNA metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001120
View Gene Order
ENSBTAG00000030775
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.617474 Hs.667593 Hs.736936
RefSeq NM_001130141 NM_020528
HUGO
OMIM
CCDS CCDS42974 CCDS46652
HPRD 10534
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca