Version 5.4
Homo sapiens Gene: PDLIM7
Summary
InnateDB Gene IDBG-60188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDLIM7
Gene Name PDZ and LIM domain 7 (enigma)
Synonyms LMP1; LMP3
Species Homo sapiens
Ensembl Gene ENSG00000196923
Encoded Proteins
IDBP-60190
PDZ and LIM domain 7 (enigma)
IDBP-60192
PDZ and LIM domain 7 (enigma)
IDBP-60198
PDZ and LIM domain 7 (enigma)
IDBP-243378
PDZ and LIM domain 7 (enigma)
IDBP-243380
PDZ and LIM domain 7 (enigma)
IDBP-593538
PDZ and LIM domain 7 (enigma)
IDBP-600644
PDZ and LIM domain 7 (enigma)
IDBP-478856
PDZ and LIM domain 7 (enigma)
IDBP-481935
PDZ and LIM domain 7 (enigma)
IDBP-481101
PDZ and LIM domain 7 (enigma)
IDBP-476312
PDZ and LIM domain 7 (enigma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177483394-177497606
Strand Reverse strand
Band q35.3
Transcripts
ENST00000355841 ENSP00000348099
ENST00000359895 ENSP00000352964
ENST00000355572 ENSP00000347776
ENST00000393551 ENSP00000377182
ENST00000393546 ENSP00000377177
ENST00000493815 ENSP00000431236
ENST00000486828 ENSP00000439157
ENST00000504380
ENST00000505746
ENST00000505074 ENSP00000426213
ENST00000506161 ENSP00000424850
ENST00000504318
ENST00000503346
ENST00000503827 ENSP00000422363
ENST00000463411
ENST00000506537 ENSP00000421664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 59 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0001503 ossification
GO:0006898 receptor-mediated endocytosis
GO:0007275 multicellular organismal development
GO:0030036 actin cytoskeleton organization
GO:0030154 cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
Cellular Component
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021493
View Gene Order
ENSBTAG00000007343
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ret_pathway
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005451 NM_203352 NM_213636 XM_006714937 XM_006714940
HUGO
OMIM
CCDS CCDS4422 CCDS4423 CCDS4424
HPRD 10436
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca