Version 5.4
Bos taurus Gene: PDLIM7
Summary
InnateDB Gene IDBG-645273.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDLIM7
Gene Name PDZ and LIM domain protein 7
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007343
Encoded Proteins
IDBP-697977
PDZ and LIM domain protein 7
IDBP-697979
PDZ and LIM domain protein 7
IDBP-697980
PDZ and LIM domain protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196923:
The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:40333461-40353545
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024902 ENSBTAP00000024902
ENSBTAT00000009661 ENSBTAP00000009661
ENSBTAT00000009662 ENSBTAP00000009662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0001503 ossification
GO:0007275 multicellular organismal development
GO:0030036 actin cytoskeleton organization
GO:0030154 cell differentiation
Cellular Component
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000196923
View Gene Order
ENSMUSG00000021493
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ret_pathway
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt Q3SX40
TrEMBL A1L5A7
UniProt Splice Variant
Entrez Gene 533851
UniGene Bt.9949
RefSeq NM_001017947 NM_001113251 XM_005209202 XM_005209203 XM_005209204 XM_005209205
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104521 BT020909 BT029894 DAAA02020055
GenPept AAI04522 AAX08926 ABM21560
RNA Seq Atlas 533851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca