InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS6KB2

Summary

InnateDB Gene

IDBG-60304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KB2

Gene Name

ribosomal protein S6 kinase, 70kDa, polypeptide 2

Synonyms

KLS; P70-beta; P70-beta-1; P70-beta-2; p70(S6K)-beta; p70S6Kb; S6K-beta2; S6K2; SRK; STK14B

Species

Homo sapiens

Ensembl Gene

ENSG00000175634

Encoded Proteins

IDBP-60306

ribosomal protein S6 kinase, 70kDa, polypeptide 2

IDBP-379446

ribosomal protein S6 kinase, 70kDa, polypeptide 2

IDBP-600639

ribosomal protein S6 kinase, 70kDa, polypeptide 2

IDBP-602262

ribosomal protein S6 kinase, 70kDa, polypeptide 2

IDBP-584224

ribosomal protein S6 kinase, 70kDa, polypeptide 2

IDBP-811950

ribosomal protein S6 kinase, 70kDa, polypeptide 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67428460-67435408

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000312629	ENSP00000308413
ENST00000420069	ENSP00000410175
ENST00000530623
ENST00000556575	ENSP00000450621
ENST00000524934	ENSP00000436811
ENST00000524814
ENST00000528964	ENSP00000432847
ENST00000525088
ENST00000525996	ENSP00000473485
ENST00000525726
ENST00000526268
ENST00000531765

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004711	ribosomal protein S6 kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042277	peptide binding

Biological Process

GO:0006412	translation
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043491	protein kinase B signaling
GO:0045087	innate immune response
GO:0045948	positive regulation of translational initiation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling