InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPS6KB2

Summary

InnateDB Protein

IDBP-60306.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KB2

Protein Name

ribosomal protein S6 kinase, 70kDa, polypeptide 2

Synonyms

KLS; P70-beta; P70-beta-1; P70-beta-2; p70(S6K)-beta; p70S6Kb; S6K-beta2; S6K2; SRK; STK14B;

Species

Homo sapiens

Ensembl Protein

ENSP00000308413

InnateDB Gene

IDBG-60304 (RPS6KB2)

Protein Structure

UniProt Annotation

Function

Phosphorylates specifically ribosomal protein S6.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004711	ribosomal protein S6 kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042277	peptide binding

Biological Process

GO:0006412	translation
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043491	protein kinase B signaling
GO:0045087	innate immune response
GO:0045948	positive regulation of translational initiation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016238 Ribosomal protein S6 kinase
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

PIRSF000605

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References