Version 5.4
Homo sapiens Gene: CPB1
Summary
InnateDB Gene IDBG-60357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPB1
Gene Name carboxypeptidase B1 (tissue)
Synonyms CPB; PASP; PCPB
Species Homo sapiens
Ensembl Gene ENSG00000153002
Encoded Proteins
IDBP-60359
carboxypeptidase B1 (tissue)
IDBP-485313
carboxypeptidase B1 (tissue)
IDBP-482621
carboxypeptidase B1 (tissue)
IDBP-480459
carboxypeptidase B1 (tissue)
IDBP-478994
carboxypeptidase B1 (tissue)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:148791102-148860187
Strand Forward strand
Band q24
Transcripts
ENST00000282957 ENSP00000282957
ENST00000491148 ENSP00000417222
ENST00000494888 ENSP00000419114
ENST00000462345 ENSP00000417117
ENST00000468341 ENSP00000419427
ENST00000465718
ENST00000484877
ENST00000473621
ENST00000498639
ENST00000476847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000011463
View Gene Order
ENSBTAG00000000456
Not yet available
Pathways
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04972
Pancreatic secretion pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.477891
RefSeq NM_001871 XM_005247124
HUGO
OMIM
CCDS CCDS33874
HPRD 00271
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca