Version 5.4
Homo sapiens Gene: CPA3
Summary
InnateDB Gene IDBG-60396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPA3
Gene Name carboxypeptidase A3 (mast cell)
Synonyms MC-CPA
Species Homo sapiens
Ensembl Gene ENSG00000163751
Encoded Proteins
IDBP-60398
carboxypeptidase A3 (mast cell)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory granule metalloexopeptidase. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:148865256-148897196
Strand Forward strand
Band q24
Transcripts
ENST00000296046 ENSP00000296046
ENST00000477926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0002002 regulation of angiotensin levels in blood
GO:0002003 angiotensin maturation
GO:0006508 proteolysis
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0030133 transport vesicle
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001865
View Gene Order
ENSBTAG00000015008
Not yet available
Pathways
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04614
Renin-angiotensin system pathway
hsa04972
Pancreatic secretion pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.646
RefSeq NM_001870 XM_006713503
HUGO
OMIM
CCDS CCDS3138
HPRD 00270
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca