Version 5.4
Homo sapiens Gene: SIRT4
Summary
InnateDB Gene IDBG-60455.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT4
Gene Name sirtuin 4
Synonyms SIR2L4
Species Homo sapiens
Ensembl Gene ENSG00000089163
Encoded Proteins
IDBP-60457
sirtuin 4
IDBP-600956
sirtuin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:120302316-120313249
Strand Forward strand
Band q24.31
Transcripts
ENST00000202967 ENSP00000202967
ENST00000536460 ENSP00000444838
ENST00000537892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0034979 NAD-dependent protein deacetylase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006342 chromatin silencing
GO:0006471 protein ADP-ribosylation
GO:0006541 glutamine metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0034983 peptidyl-lysine deacetylation
GO:0046322 negative regulation of fatty acid oxidation
GO:0046676 negative regulation of insulin secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0072350 tricarboxylic acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029524
View Gene Order
ENSBTAG00000021168
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.50861
RefSeq NM_012240 XM_006719308 XM_006719309 XM_006719310 XM_006719311 XM_006719312
HUGO
OMIM
CCDS CCDS9194
HPRD 06837
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca