Version 5.4
Bos taurus Gene: SIRT4
Summary
InnateDB Gene IDBG-634750.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT4
Gene Name NAD-dependent protein deacetylase sirtuin-4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021168
Encoded Proteins
IDBP-686539
NAD-dependent ADP-ribosyltransferase sirtuin-4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089163:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64875357-64891606
Strand Forward strand
Band
Transcripts
ENSBTAT00000028210 ENSBTAP00000028210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0034979 NAD-dependent protein deacetylase activity
GO:0046872 metal ion binding
GO:0070403 NAD+ binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0006541 glutamine metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0034983 peptidyl-lysine deacetylation
GO:0046322 negative regulation of fatty acid oxidation
GO:0046676 negative regulation of insulin secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0072350 tricarboxylic acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000089163
View Gene Order
ENSMUSG00000029524
View Gene Order
Cross-References
SwissProt Q1JQC6
TrEMBL C6K7D5
UniProt Splice Variant
Entrez Gene 519328
UniGene Bt.39710
RefSeq NM_001075785 XM_005217844 XM_005217846 XM_005217847 XM_005217848
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116055 GQ166650
GenPept AAI16056 ACS66700
RNA Seq Atlas 519328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca