Version 5.4
Mus musculus Gene: Myl6
Summary
InnateDB Gene IDBG-605265.2
Last Modified 2013-04-25 [Report errors or provide feedback]
Gene Symbol Myl6
Gene Name myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Synonyms ESMLC; LC17; LC17-GI; LC17-NM; LC17A; LC17B; MLC-3; MLC1SM; MLC3nm; MLC3SM; Myln
Species Mus musculus
Ensembl Gene ENSMUSG00000090841
Encoded Proteins
IDBP-620655
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092841:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128490860-128493875
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000164181 ENSMUSP00000128803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0030898 actin-dependent ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006936 muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0008152 metabolic process
GO:0030049 muscle filament sliding
Cellular Component
GO:0016020 membrane
GO:0016459 myosin complex
GO:0016461 unconventional myosin complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000092841
View Gene Order
ENSBTAG00000010799
Not yet available
Pathways
NETPATH
REACTOME
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_235059
Smooth Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
REACT_246650
Sema4D induced cell migration and growth-cone collapse pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_261444
Axon guidance pathway
REACT_234744
Sema4D in semaphorin signaling pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
KEGG
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_20558
Smooth Muscle Contraction pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_17044
Muscle contraction pathway
REACT_231337
EPHA-mediated growth cone collapse pathway
REACT_211252
Sema4D in semaphorin signaling pathway
REACT_213099
Muscle contraction pathway
REACT_218808
Sema4D induced cell migration and growth-cone collapse pathway
REACT_217010
Smooth Muscle Contraction pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_203140
Axon guidance pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt Q60605
TrEMBL B0LAC7 Q642K0
UniProt Splice Variant
Entrez Gene 17904
UniGene Mm.208004
RefSeq NM_010860 XM_006531565 XM_006544375
OMIM
CCDS CCDS48728
HPRD
IMGT
MGI ID MGI:109318
MGI Symbol Myl6
EMBL AK167106 AK167191 AK168450 AK168869 BC026760 BC081470 BC089485 BC092214 CH466578 EF437355 U04443
GenPept AAC52278 AAH26760 AAH81470 AAH89485 AAH92214 ABS83521 BAE39255 BAE39321 BAE40353 BAE40688 EDL24571
RNA Seq Atlas 102635661 17904

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca