Version 5.4
Mus musculus Gene: Ube2d2a
Summary
InnateDB Gene IDBG-605562.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2d2a
Gene Name ubiquitin-conjugating enzyme E2D 2A
Synonyms 1500034D03Rik; Ubc2e; ubc4; Ube2d2
Species Mus musculus
Ensembl Gene ENSMUSG00000091896
Encoded Proteins
IDBP-621951
ubiquitin-conjugating enzyme E2D 2
IDBP-621952
ubiquitin-conjugating enzyme E2D 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131508:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Jul 2008]
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:35771559-35807172
Strand Forward strand
Band B2
Transcripts
ENSMUST00000170693 ENSMUSP00000132446
ENSMUST00000167406 ENSMUSP00000131206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 196 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 196 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131508
View Gene Order
ENSBTAG00000004161
Not yet available
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_188957
Cellular responses to stress pathway
REACT_199106
Cellular response to hypoxia pathway
REACT_230745
Immune System pathway
REACT_199108
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_199109
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_226192
IKK complex recruitment mediated by RIP1 pathway
REACT_241786
MyD88-independent cascade pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_120956
Cellular responses to stress pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_75774
Adaptive Immune System pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_6900
Immune System pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_222387
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_224546
MyD88-independent cascade pathway
REACT_204964
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_202328
IKK complex recruitment mediated by RIP1 pathway
REACT_206069
Cellular responses to stress pathway
REACT_213138
Immune System pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_216714
Innate Immune System pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_210460
Cellular response to hypoxia pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
Cross-References
SwissProt P62838
TrEMBL Q3UT95
UniProt Splice Variant
Entrez Gene 56550
UniGene Mm.398417 Mm.471327 Mm.490368
RefSeq NM_019912
OMIM
CCDS CCDS50254
HPRD
IMGT
MGI ID MGI:1930715
MGI Symbol Ube2d2a
EMBL AK136197 AK139623 AK148089 AK160567 AK162093 BC003923 CH466557 U62483
GenPept AAB05772 AAH03923 BAE22869 BAE24085 BAE28338 BAE35877 BAE36719 EDK97145
RNA Seq Atlas 56550

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca