Version 5.4
Mus musculus Gene: Peg10
Summary
InnateDB Gene IDBG-605798.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Peg10
Gene Name paternally expressed 10
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000092035
Encoded Proteins
IDBP-623037
paternally expressed 10
IDBP-714889
IDBP-715499
IDBP-715641
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Knockout studies in mice suggest that this gene is critical for parthenogenetic development. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:4747306-4760517
Strand Forward strand
Band A1
Transcripts
ENSMUST00000166678 ENSMUSP00000127306
ENSMUST00000176204 ENSMUSP00000134963
ENSMUST00000175823 ENSMUSP00000135653
ENSMUST00000176551 ENSMUSP00000135076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001890 placenta development
GO:0006915 apoptotic process
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000242265
View Gene Order
ENSBTAG00000038093
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL H3BL51
UniProt Splice Variant
Entrez Gene 170676
UniGene Mm.320575 Mm.471407
RefSeq NM_001040611 NM_130877
OMIM
CCDS CCDS57407
HPRD
IMGT
MGI ID MGI:2157785
MGI Symbol Peg10
EMBL AC084315
GenPept
RNA Seq Atlas 170676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca