InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PEG10

Summary

InnateDB Gene

IDBG-409089.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEG10

Gene Name

paternally expressed 10

Synonyms

EDR; HB-1; Mar2; Mart2; MEF3L; RGAG3

Species

Homo sapiens

Ensembl Gene

ENSG00000242265

Encoded Proteins

IDBP-481049

paternally expressed 10

IDBP-482080

paternally expressed 10

IDBP-807454

paternally expressed 10

IDBP-807455

paternally expressed 10

IDBP-807467

paternally expressed 10

IDBP-807468

paternally expressed 10

IDBP-807469

paternally expressed 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:94656325-94669695

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000482108	ENSP00000417587
ENST00000488574	ENSP00000418944
ENST00000493935
ENST00000465184
ENST00000612748	ENSP00000480676
ENST00000613043	ENSP00000482046
ENST00000617526	ENSP00000481101
ENST00000615790	ENSP00000482653
ENST00000612941	ENSP00000478744

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001890	placenta development
GO:0006915	apoptotic process
GO:0030154	cell differentiation
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000092035

View Gene Order

ENSBTAG00000038093

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

23089

UniGene

RefSeq

NM_001184962 NM_001040152 NM_001172437 NM_001172438 NM_001184961 NM_015068

HUGO

HGNC:14005

OMIM

609810

CCDS

CCDS75637 CCDS55126 CCDS75636

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

23089