Version 5.4
Homo sapiens Gene: CDK16
Summary
InnateDB Gene IDBG-60588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK16
Gene Name cyclin-dependent kinase 16
Synonyms PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1
Species Homo sapiens
Ensembl Gene ENSG00000102225
Encoded Proteins
IDBP-60590
cyclin-dependent kinase 16
IDBP-60592
cyclin-dependent kinase 16
IDBP-369195
cyclin-dependent kinase 16
IDBP-478769
cyclin-dependent kinase 16
IDBP-483833
cyclin-dependent kinase 16
IDBP-483581
cyclin-dependent kinase 16
IDBP-481373
cyclin-dependent kinase 16
IDBP-483304
cyclin-dependent kinase 16
IDBP-478255
cyclin-dependent kinase 16
IDBP-483072
cyclin-dependent kinase 16
IDBP-473363
cyclin-dependent kinase 16
IDBP-479784
cyclin-dependent kinase 16
IDBP-481300
cyclin-dependent kinase 16
IDBP-481102
cyclin-dependent kinase 16
IDBP-807107
cyclin-dependent kinase 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47217860-47229997
Strand Forward strand
Band p11.3
Transcripts
ENST00000276052 ENSP00000276052
ENST00000357227 ENSP00000349762
ENST00000457458 ENSP00000405798
ENST00000428400
ENST00000517997
ENST00000517479
ENST00000522883 ENSP00000431085
ENST00000520295 ENSP00000430966
ENST00000519758 ENSP00000429259
ENST00000520893 ENSP00000428351
ENST00000517426 ENSP00000429985
ENST00000522234
ENST00000518391 ENSP00000429044
ENST00000518022 ENSP00000429751
ENST00000523034 ENSP00000430486
ENST00000523344 ENSP00000428349
ENST00000523699
ENST00000523543
ENST00000493213
ENST00000520141 ENSP00000430988
ENST00000462827 ENSP00000430824
ENST00000462483
ENST00000622098 ENSP00000482886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 23 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006887 exocytosis
GO:0007283 spermatogenesis
GO:0030252 growth hormone secretion
GO:0031175 neuron projection development
GO:0051726 regulation of cell cycle
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0015630 microtubule cytoskeleton
GO:0030054 cell junction
GO:0030133 transport vesicle
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031065
View Gene Order
ENSBTAG00000016769
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597538 Hs.739486
RefSeq NM_001170460 NM_006201 NM_033018
HUGO
OMIM
CCDS CCDS14276 CCDS48101 CCDS55408
HPRD 02409
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca