Version 5.4
Homo sapiens Gene: CP
Summary
InnateDB Gene IDBG-60595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CP
Gene Name ceruloplasmin (ferroxidase)
Synonyms CP-2
Species Homo sapiens
Ensembl Gene ENSG00000047457
Encoded Proteins
IDBP-60597
ceruloplasmin (ferroxidase)
IDBP-478697
ceruloplasmin (ferroxidase)
IDBP-476559
ceruloplasmin (ferroxidase)
IDBP-476016
ceruloplasmin (ferroxidase)
IDBP-479928
ceruloplasmin (ferroxidase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:149162410-149222055
Strand Reverse strand
Band q25.1
Transcripts
ENST00000264613 ENSP00000264613
ENST00000455472 ENSP00000426888
ENST00000481169 ENSP00000418773
ENST00000479771 ENSP00000420367
ENST00000460674
ENST00000494544 ENSP00000420545
ENST00000474204
ENST00000473296
ENST00000463556
ENST00000490639
ENST00000497902
ENST00000462336
ENST00000489736
ENST00000497797
ENST00000471356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004322 ferroxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0051087 chaperone binding
Biological Process
GO:0006825 copper ion transport
GO:0006879 cellular iron ion homeostasis
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003617
View Gene Order
ENSBTAG00000012164
Not yet available
Pathways
NETPATH
REACTOME
REACT_25060
Iron uptake and transport pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.558314 Hs.670968 Hs.694651 Hs.732558
RefSeq NM_000096 XM_006713500 XM_006713502
HUGO
OMIM
CCDS CCDS3141
HPRD 00317
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca