InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CP

Summary

InnateDB Protein

IDBP-60597.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

ceruloplasmin (ferroxidase)

Synonyms

CP-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000264613

InnateDB Gene

IDBG-60595 (CP)

Protein Structure

UniProt Annotation

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments. {ECO:0000250}.

Disease Associations

Aceruloplasminemia (ACERULOP) [MIM:604290]: An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.

Tissue Specificity

Expressed by the liver and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0005507	copper ion binding
GO:0016491	oxidoreductase activity
GO:0051087	chaperone binding

Biological Process

GO:0006825	copper ion transport
GO:0006879	cellular iron ion homeostasis
GO:0055085	transmembrane transport
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle