Version 5.4
Homo sapiens Gene: TM4SF1
Summary
InnateDB Gene IDBG-60707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TM4SF1
Gene Name transmembrane 4 L six family member 1
Synonyms H-L6; L6; M3S1; TAAL6
Species Homo sapiens
Ensembl Gene ENSG00000169908
Encoded Proteins
IDBP-60709
transmembrane 4 L six family member 1
IDBP-479229
transmembrane 4 L six family member 1
IDBP-483141
transmembrane 4 L six family member 1
IDBP-479751
transmembrane 4 L six family member 1
IDBP-808764
transmembrane 4 L six family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:149369022-149377865
Strand Reverse strand
Band q25.1
Transcripts
ENST00000305366 ENSP00000304277
ENST00000472441 ENSP00000417084
ENST00000493348 ENSP00000419426
ENST00000493298 ENSP00000418025
ENST00000622124 ENSP00000477606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027800
View Gene Order
ENSBTAG00000015163
Not yet available
Cross-References
SwissProt
TrEMBL F8WBG6
UniProt Splice Variant
Entrez Gene 4071
UniGene Hs.740377
RefSeq NM_014220
HUGO HGNC:11853
OMIM 191155
CCDS CCDS3143
HPRD 01854
IMGT
EMBL AC073522 AC108751
GenPept
RNA Seq Atlas 4071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca