Version 5.4
Homo sapiens Gene: EPX
Summary
InnateDB Gene IDBG-60745.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPX
Gene Name eosinophil peroxidase
Synonyms EPO; EPP; EPX-PEN
Species Homo sapiens
Ensembl Gene ENSG00000121053
Encoded Proteins
IDBP-60747
eosinophil peroxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:58192737-58205174
Strand Forward strand
Band q22
Transcripts
ENST00000225371 ENSP00000225371
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0002215 defense response to nematode
GO:0006979 response to oxidative stress
GO:0032693 negative regulation of interleukin-10 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042744 hydrogen peroxide catabolic process
GO:0055114 oxidation-reduction process
GO:0072677 eosinophil migration
Cellular Component
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000052234
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa05310
Asthma pathway
INOH
PID NCI
Cross-References
SwissProt P11678
TrEMBL
UniProt Splice Variant
Entrez Gene 8288
UniGene Hs.279259
RefSeq NM_000502 XM_006722128
HUGO HGNC:3423
OMIM 131399
CCDS CCDS11602
HPRD
IMGT
EMBL DQ054598 M29904 M29905 M29906 M29907 M29908 M29909 M29910 M29911 M29912 M29913 X14346
GenPept AAA58458 AAY43126 CAA32530
RNA Seq Atlas 8288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca