InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPX

Summary

InnateDB Protein

IDBP-60747.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPX

Protein Name

eosinophil peroxidase

Synonyms

EPO; EPP; EPX-PEN;

Species

Homo sapiens

Ensembl Protein

ENSP00000225371

InnateDB Gene

IDBG-60745 (EPX)

Protein Structure

UniProt Annotation

Function

Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. {ECO:0000269PubMed:12540536, ECO:0000269PubMed:18694936}.

Subcellular Localization

Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Disease Associations

Eosinophil peroxidase deficiency (EPXD) [MIM:261500]: A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils. {ECO:0000269PubMed:7809065}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0002215	defense response to nematode
GO:0006979	response to oxidative stress
GO:0032693	negative regulation of interleukin-10 production
GO:0032714	negative regulation of interleukin-5 production
GO:0032753	positive regulation of interleukin-4 production
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process
GO:0072677	eosinophil migration