Version 5.4
Homo sapiens Gene: PFN2
Summary
InnateDB Gene IDBG-60946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFN2
Gene Name profilin 2
Synonyms D3S1319E; PFL
Species Homo sapiens
Ensembl Gene ENSG00000070087
Encoded Proteins
IDBP-60948
profilin 2
IDBP-384840
profilin 2
IDBP-384843
profilin 2
IDBP-482366
profilin 2
IDBP-474102
profilin 2
IDBP-480075
profilin 2
IDBP-475494
profilin 2
IDBP-479202
profilin 2
IDBP-481013
profilin 2
IDBP-484165
profilin 2
IDBP-479206
profilin 2
IDBP-479786
profilin 2
IDBP-473891
profilin 2
IDBP-479108
profilin 2
IDBP-478305
profilin 2
IDBP-482475
profilin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:149964904-150050788
Strand Reverse strand
Band q25.1
Transcripts
ENST00000239940 ENSP00000239940
ENST00000452853 ENSP00000410464
ENST00000423691 ENSP00000408283
ENST00000481767 ENSP00000420417
ENST00000460404 ENSP00000417924
ENST00000468323 ENSP00000418494
ENST00000494827 ENSP00000418523
ENST00000497060
ENST00000490975 ENSP00000417351
ENST00000497148 ENSP00000417817
ENST00000498169 ENSP00000418521
ENST00000475518 ENSP00000418142
ENST00000481275 ENSP00000418216
ENST00000498307 ENSP00000420202
ENST00000489155 ENSP00000420504
ENST00000461930 ENSP00000417912
ENST00000461868 ENSP00000420244
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process
GO:0010633 negative regulation of epithelial cell migration
GO:0030036 actin cytoskeleton organization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0051496 positive regulation of stress fiber assembly
GO:1900028 negative regulation of ruffle assembly
GO:2000300 regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0043195 terminal bouton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027805
View Gene Order
ENSBTAG00000011150
Not yet available
Pathways
NETPATH
REACTOME
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.91747
RefSeq NM_002628 NM_053024
HUGO
OMIM
CCDS CCDS3148 CCDS46934
HPRD 01451
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca