InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pfn2

Summary

InnateDB Gene

IDBG-146219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfn2

Gene Name

profilin 2

Synonyms

Pfn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027805

Encoded Proteins

IDBP-146221

profilin 2

IDBP-401424

profilin 2

IDBP-401433

profilin 2

IDBP-401426

profilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070087:
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:57841895-57847564

Strand

Reverse strand

Band

Transcripts

ENSMUST00000066882	ENSMUSP00000068890
ENSMUST00000119344	ENSMUSP00000112391
ENSMUST00000122210	ENSMUSP00000113526
ENSMUST00000120289	ENSMUSP00000112443

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000774	adenyl-nucleotide exchange factor activity
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding

Biological Process

GO:0010633	negative regulation of epithelial cell migration
GO:0030036	actin cytoskeleton organization
GO:0030837	negative regulation of actin filament polymerization
GO:0030838	positive regulation of actin filament polymerization
GO:0032233	positive regulation of actin filament bundle assembly
GO:0032781	positive regulation of ATPase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0051496	positive regulation of stress fiber assembly
GO:1900028	negative regulation of ruffle assembly
GO:2000300	regulation of synaptic vesicle exocytosis