Homo sapiens Gene: UNC93B1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-61027.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | UNC93B1 | ||||||||||||||||||||||
Gene Name | unc-93 homolog B1 (C. elegans) | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000110057 | ||||||||||||||||||||||
Encoded Proteins |
unc-93 homolog B1 (C. elegans)
unc-93 homolog B1 (C. elegans)
unc-93 homolog B1 (C. elegans)
unc-93 homolog B1 (C. elegans)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
UNC93B1 is a polytopic membrane protein that delivers the nucleotide sensing receptors TLR7 and TLR9 from the endoplasmic reticulum to endolysosomes.
UNC93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. UNC93B1 has a critical role on induction of IL-12/IFN-gamma production as well as autonomous control of Toxoplasma replication by macrophages.
UNC93B1 controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in UNC93B1 causes TLR7-dependent systemic lethal inflammation. (Demonstrated in murine model)
UNC93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.
UNC93B1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs).
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] Unc93b1 is a resident endoplasmic reticulum protein that interacts with Tlr11 to regulate the dendritic cell activation in response to T. gondii profilin and parasitic infection.
[Mus musculus] Unc93b1 controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in Unc93b1 causes Tlr7-dependent systemic lethal inflammation.
[Mus musculus] Unc93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.
[Mus musculus] Unc93b1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs ). (Demonstrated in human)
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:67991104-68004982 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q13.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Trafficking and processing of endosomal TLR pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.502989 Hs.568937 | ||||||||||||||||||||||
RefSeq | NM_030930 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS73334 | ||||||||||||||||||||||
HPRD | 12191 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||