InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.53643

Summary

InnateDB Gene

IDBG-644826.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.53643

Gene Name

protein unc-93 homolog B1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001193

Encoded Proteins

IDBP-697496

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18305481

[Homo sapiens] UNC93B1 is a polytopic membrane protein that delivers the nucleotide sensing receptors TLR7 and TLR9 from the endoplasmic reticulum to endolysosomes.

PMID 19451267

[Homo sapiens] UNC93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.

PMID 20865117

[Homo sapiens] UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. UNC93B1 has a critical role on induction of IL-12/IFN-gamma production as well as autonomous control of Toxoplasma replication by macrophages.

PMID 21683627

[Homo sapiens] UNC93B1 controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in UNC93B1 causes TLR7-dependent systemic lethal inflammation. (Demonstrated in murine model)

PMID 21683627

[Homo sapiens] UNC93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.

PMID 22164301

[Homo sapiens] UNC93B1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs).

PMID 21097503

[Mus musculus] Unc93b1 is a resident endoplasmic reticulum protein that interacts with Tlr11 to regulate the dendritic cell activation in response to T. gondii profilin and parasitic infection.

PMID 21683627

[Mus musculus] Unc93b1 controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in Unc93b1 causes Tlr7-dependent systemic lethal inflammation.

PMID 21683627

[Mus musculus] Unc93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.

PMID 22164301

[Mus musculus] Unc93b1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs ). (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110057:
This gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:46162697-46172747

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001581

ENSBTAP00000001581

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035325	Toll-like receptor binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0006886	intracellular protein transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034154	toll-like receptor 7 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway