Version 5.4
Homo sapiens Gene: IZUMO1
Summary
InnateDB Gene IDBG-61071.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IZUMO1
Gene Name izumo sperm-egg fusion 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182264
Encoded Proteins
IDBP-61073
izumo sperm-egg fusion 1
IDBP-765163
IDBP-765321
IDBP-763810
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48740852-48746909
Strand Reverse strand
Band q13.33
Transcripts
ENST00000332955 ENSP00000327786
ENST00000597553
ENST00000595517 ENSP00000471815
ENST00000595937 ENSP00000470144
ENST00000602105 ENSP00000471134
ENST00000599871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007155 cell adhesion
GO:0007338 single fertilization
GO:0007342 fusion of sperm to egg plasma membrane
GO:0032504 multicellular organism reproduction
GO:0035036 sperm-egg recognition
Cellular Component
GO:0001669 acrosomal vesicle
GO:0002080 acrosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064158
View Gene Order
ENSBTAG00000011621
Not yet available
Pathways
NETPATH
REACTOME
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
REACT_164006
Sperm:Oocyte Membrane Binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_182575 XM_005258797
HUGO
OMIM
CCDS CCDS12732
HPRD 14589
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca