Version 5.4
Homo sapiens Protein: IZUMO1
Summary
InnateDB Protein IDBP-61073.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IZUMO1
Protein Name izumo sperm-egg fusion 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000327786
InnateDB Gene IDBG-61071 (IZUMO1)
Protein Structure
UniProt Annotation
Function Essential sperm cell-surface protein required for fertilization by acting as a ligand for FOLR4/JUNO receptor on egg. The IZUMO1:FOLR4/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269PubMed:15759005}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. {ECO:0000269PubMed:15759005}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007155 cell adhesion
GO:0007338 single fertilization
GO:0007342 fusion of sperm to egg plasma membrane
GO:0032504 multicellular organism reproduction
GO:0035036 sperm-egg recognition
Cellular Component
GO:0001669 acrosomal vesicle
GO:0002080 acrosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IYV9
PhosphoSite PhosphoSite-Q8IYV9
TrEMBL
UniProt Splice Variant
Entrez Gene 284359
UniGene
RefSeq NP_872381
HUGO HGNC:28539
OMIM 609278
CCDS CCDS12732
HPRD 14589
IMGT
EMBL AB195682 AC009002 AY552609 AY552610 BC034769
GenPept AAH34769 AAS59145 AAS59146 BAD91012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca