InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAK

Summary

InnateDB Gene

IDBG-61290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAK

Gene Name

male germ cell-associated kinase

Synonyms

dJ417M14.2; RP62

Species

Homo sapiens

Ensembl Gene

ENSG00000111837

Encoded Proteins

IDBP-61292

male germ cell-associated kinase

IDBP-61294

male germ cell-associated kinase

IDBP-812947

male germ cell-associated kinase

IDBP-603897

male germ cell-associated kinase

IDBP-587406

male germ cell-associated kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:10762723-10838555

Strand

Reverse strand

Band

p24.2

Transcripts

ENST00000313243	ENSP00000313021
ENST00000354489	ENSP00000346484
ENST00000474039	ENSP00000476067
ENST00000538030	ENSP00000442250
ENST00000536370	ENSP00000442221

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0045494	photoreceptor cell maintenance
GO:0046777	protein autophosphorylation
GO:0051726	regulation of cell cycle

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0030496	midbody
GO:0072686	mitotic spindle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021363

View Gene Order

ENSBTAG00000014053

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

Q8IXN4

UniProt Splice Variant

Entrez Gene

4117

UniGene

Hs.711699 Hs.739993

RefSeq

NM_001242385 NM_001242957 NM_005906 XM_006715098

HUGO

HGNC:6816

OMIM

154235

CCDS

CCDS4516 CCDS75398 CCDS75399

HPRD

01101

IMGT

EMBL

AL024498 BC039825

GenPept

AAH39825

RNA Seq Atlas

4117