InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mak

Summary

InnateDB Gene

IDBG-146618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mak

Gene Name

male germ cell-associated kinase

Synonyms

A930010O05Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021363

Encoded Proteins

IDBP-146620

male germ cell-associated kinase

IDBP-146622

male germ cell-associated kinase

IDBP-620275

male germ cell-associated kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111837:
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:41025120-41079706

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000021792	ENSMUSP00000021792
ENSMUST00000070193	ENSMUSP00000064750
ENSMUST00000165087	ENSMUSP00000129615

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0045494	photoreceptor cell maintenance
GO:0046777	protein autophosphorylation

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0030496	midbody
GO:0072686	mitotic spindle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111837

View Gene Order

ENSBTAG00000014053

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

Q04859

TrEMBL

UniProt Splice Variant

Entrez Gene

17152

UniGene

Mm.8149

RefSeq

NM_001145802 NM_001145803 NM_008547 XM_006516868 XM_006516869 XM_006516870 XM_006516871 XM_006516872

OMIM

CCDS

CCDS26471 CCDS49244 CCDS49245

HPRD

IMGT

MGI ID

MGI:96913

MGI Symbol

Mak

EMBL

AC133496 AK029894 X66983

GenPept

BAC26662 CAA47392

RNA Seq Atlas

17152