Version 5.4
Homo sapiens Gene: DHDH
Summary
InnateDB Gene IDBG-61438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHDH
Gene Name dihydrodiol dehydrogenase (dimeric)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104808
Encoded Proteins
IDBP-61440
dihydrodiol dehydrogenase (dimeric)
IDBP-484459
dihydrodiol dehydrogenase (dimeric)
IDBP-484520
dihydrodiol dehydrogenase (dimeric)
IDBP-481418
dihydrodiol dehydrogenase (dimeric)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48933682-48944969
Strand Forward strand
Band q13.33
Transcripts
ENST00000221403 ENSP00000221403
ENST00000523250 ENSP00000428935
ENST00000522614 ENSP00000428672
ENST00000520557 ENSP00000430360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008746 NAD(P)+ transhydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0042843 D-xylose catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000011382
View Gene Order
ENSBTAG00000013337
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00040
Pentose and glucuronate interconversions pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
PID NCI
Cross-References
SwissProt Q9UQ10
TrEMBL
UniProt Splice Variant
Entrez Gene 27294
UniGene
RefSeq NM_014475
HUGO HGNC:17887
OMIM 606377
CCDS CCDS12741
HPRD 08399
IMGT
EMBL AB021933 BC032730 CH471177
GenPept AAH32730 BAA83490 EAW52414
RNA Seq Atlas 27294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca