Homo sapiens Gene: CAMKK2 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-61470.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | CAMKK2 | ||||||||||||||||||||
Gene Name | calcium/calmodulin-dependent protein kinase kinase 2, beta | ||||||||||||||||||||
Synonyms | CAMKK; CAMKKB | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000110931 | ||||||||||||||||||||
Encoded Proteins |
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
calcium/calmodulin-dependent protein kinase kinase 2, beta
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||
Summary |
CAMKK2-null macrophages exhibited deficiency to spread, phagocytize bacteria and synthesize cytokines in response to the Toll Like Receptor 4 (TLR4) agonist lipopolysaccharide (LPS). (Demonstrated in mice)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||
Summary |
[Mus musculus] Camkk2-null macrophages exhibited deficiency to spread, phagocytize bacteria and synthesize cytokines in response to the Toll Like Receptor 4 (TLR4) agonist lipopolysaccharide (LPS).
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Entrez Gene | |||||||||||||||||||||
Summary |
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 12:121237691-121298308 | ||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||
Band | q24.31 | ||||||||||||||||||||
Transcripts | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME | |||||||||||||||||||||
KEGG |
Adipocytokine signaling pathway pathway
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INOH | |||||||||||||||||||||
PID NCI |
Signaling events mediated by VEGFR1 and VEGFR2
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
UniGene | Hs.297343 Hs.621928 | ||||||||||||||||||||
RefSeq | NM_001270485 NM_001270486 NM_006549 NM_153499 NM_153500 NM_172214 NM_172215 NM_172216 NM_172226 XM_005253822 XM_005253823 XM_005253824 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS44999 CCDS53837 CCDS58283 CCDS9216 CCDS9217 CCDS9218 CCDS9219 | ||||||||||||||||||||
HPRD | 06467 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | |||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||