InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Camkk2

Summary

InnateDB Gene

IDBG-198659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camkk2

Gene Name

calcium/calmodulin-dependent protein kinase kinase 2, beta

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029471

Encoded Proteins

IDBP-257632

calcium/calmodulin-dependent protein kinase kinase 2, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22334678

Camkk2-null macrophages exhibited deficiency to spread, phagocytize bacteria and synthesize cytokines in response to the Toll Like Receptor 4 (TLR4) agonist lipopolysaccharide (LPS).

InnateDB Annotation from Orthologs

Summary

PMID 22334678

[Homo sapiens] CAMKK2-null macrophages exhibited deficiency to spread, phagocytize bacteria and synthesize cytokines in response to the Toll Like Receptor 4 (TLR4) agonist lipopolysaccharide (LPS). (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110931:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:122731173-122779410

Strand

Reverse strand

Band

Transcripts

ENSMUST00000111668

ENSMUSP00000107297

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0042995	cell projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000110931

View Gene Order

ENSBTAG00000010815

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04920

Adipocytokine signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04920

Adipocytokine signaling pathway pathway

INOH

PID NCI

vegfr1_2_pathway

Signaling events mediated by VEGFR1 and VEGFR2

Cross-References

SwissProt

Q8C078

TrEMBL

UniProt Splice Variant

Entrez Gene

207565

UniGene

Mm.394637 Mm.412845 Mm.474852

RefSeq

NM_001199676 NM_145358 XM_006530234

OMIM

CCDS

CCDS19655

HPRD

IMGT

MGI ID

MGI:2444812

MGI Symbol

Camkk2

EMBL

AF453383 AK031399 AK032070 AK044660 AK122370 BC023103

GenPept

AAH23103 AAN75696 BAC27387 BAC27681 BAC32023 BAC65652

RNA Seq Atlas

207565