InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P2RY12

Summary

InnateDB Gene

IDBG-61579.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY12

Gene Name

purinergic receptor P2Y, G-protein coupled, 12

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000169313

Encoded Proteins

IDBP-61581

purinergic receptor P2Y, G-protein coupled, 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:151337380-151384812

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000302632	ENSP00000307259
ENST00000468596

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001609	G-protein coupled adenosine receptor activity
GO:0001621	ADP receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity

Biological Process

GO:0001973	adenosine receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0010700	negative regulation of norepinephrine secretion
GO:0030030	cell projection organization
GO:0030168	platelet activation
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0043270	positive regulation of ion transport
GO:0043491	protein kinase B signaling
GO:0043547	positive regulation of GTPase activity
GO:0045596	negative regulation of cell differentiation
GO:0051924	regulation of calcium ion transport
GO:0070527	platelet aggregation
GO:0070588	calcium ion transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0009925	basal plasma membrane
GO:0016021	integral component of membrane
GO:0031224	intrinsic component of membrane