InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FTL

Summary

InnateDB Gene

IDBG-61607.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FTL

Gene Name

ferritin, light polypeptide

Synonyms

LFTD; NBIA3

Species

Homo sapiens

Ensembl Gene

ENSG00000087086

Encoded Proteins

IDBP-61611

ferritin, light polypeptide

IDBP-807096

ferritin, light polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48965301-48966878

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000331825	ENSP00000366525
ENST00000622577	ENSP00000484043

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008199	ferric iron binding
GO:0042802	identical protein binding

Biological Process

GO:0006826	iron ion transport
GO:0006879	cellular iron ion homeostasis
GO:0006892	post-Golgi vesicle-mediated transport
GO:0008219	cell death
GO:0055072	iron ion homeostasis
GO:0055085	transmembrane transport
GO:0061024	membrane organization