InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SYN1

Summary

InnateDB Gene

IDBG-61612.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYN1

Gene Name

synapsin I

Synonyms

SYN1a; SYN1b; SYNI

Species

Homo sapiens

Ensembl Gene

ENSG00000008056

Encoded Proteins

IDBP-61614

synapsin I

IDBP-61616

synapsin I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:47571898-47619853

Strand

Reverse strand

Band

p11.23

Transcripts

ENST00000295987	ENSP00000295987
ENST00000340666	ENSP00000343206

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003824	catalytic activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019901	protein kinase binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0008152	metabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043229	intracellular organelle

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000037217

View Gene Order

Pathways

NETPATH

REACTOME

REACT_15293

Dopamine Neurotransmitter Release Cycle pathway

REACT_15425

Serotonin Neurotransmitter Release Cycle pathway

REACT_13685

Neuronal System pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_13723

Neurotransmitter Release Cycle pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P17600

TrEMBL

UniProt Splice Variant

Entrez Gene

6853

UniGene

Hs.225936

RefSeq

NM_133499 NM_006950

HUGO

HGNC:11494

OMIM

313440

CCDS

CCDS35233 CCDS14280

HPRD

02433

IMGT

EMBL

AL009172 CH471164 M55301 M58321 M58341 M58351 M58353 M58359 M58371 M58372 M58373 M58374 M58375 M58376 M58377 M58378 Z84466

GenPept

AAA60608 AAC41930 AAC41931 CAI42445 CAI42446 CAI42461 CAI42462 EAW59313

RNA Seq Atlas

6853