Homo sapiens Gene: MRPL21 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-61628.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | MRPL21 | ||||||||||||||||||
Gene Name | mitochondrial ribosomal protein L21 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000197345 | ||||||||||||||||||
Encoded Proteins |
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 11:68891276-68903835 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q13.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
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KEGG |
Ribosome pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q7Z2W9 | ||||||||||||||||||
TrEMBL | A0A024R5G7 F5H4R5 F5H7V8 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 219927 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_181514 NM_181515 XM_005273823 | ||||||||||||||||||
HUGO | HGNC:14479 | ||||||||||||||||||
OMIM | 611834 | ||||||||||||||||||
CCDS | CCDS8186 CCDS44662 | ||||||||||||||||||
HPRD | 14747 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AP000808 BC055088 BM915440 CH471076 | ||||||||||||||||||
GenPept | AAH55088 EAW74724 EAW74725 | ||||||||||||||||||
RNA Seq Atlas | 219927 | ||||||||||||||||||