Homo sapiens Gene: MRPL21
Summary
InnateDB Gene IDBG-61628.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL21
Gene Name mitochondrial ribosomal protein L21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197345
Encoded Proteins
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
mitochondrial ribosomal protein L21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68891276-68903835
Strand Reverse strand
Band q13.3
Transcripts
ENST00000362034 ENSP00000354580
ENST00000450904 ENSP00000389400
ENST00000541279 ENSP00000442243
ENST00000544567 ENSP00000438837
ENST00000541265 ENSP00000445009
ENST00000536637
ENST00000567045 ENSP00000457859
ENST00000565125 ENSP00000456520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt Q7Z2W9
TrEMBL A0A024R5G7 F5H4R5 F5H7V8
UniProt Splice Variant
Entrez Gene 219927
UniGene
RefSeq NM_181514 NM_181515 XM_005273823
HUGO HGNC:14479
OMIM 611834
CCDS CCDS8186 CCDS44662
HPRD 14747
IMGT
EMBL AP000808 BC055088 BM915440 CH471076
GenPept AAH55088 EAW74724 EAW74725
RNA Seq Atlas 219927