Version 5.4
Homo sapiens Gene: HIVEP1
Summary
InnateDB Gene IDBG-61740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIVEP1
Gene Name human immunodeficiency virus type I enhancer binding protein 1
Synonyms CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1; Schnurri-1; ZAS1; ZNF40; ZNF40A
Species Homo sapiens
Ensembl Gene ENSG00000095951
Encoded Proteins
IDBP-61742
human immunodeficiency virus type I enhancer binding protein 1
IDBP-230590
human immunodeficiency virus type I enhancer binding protein 1
IDBP-362245
human immunodeficiency virus type I enhancer binding protein 1
IDBP-478148
human immunodeficiency virus type I enhancer binding protein 1
IDBP-484913
human immunodeficiency virus type I enhancer binding protein 1
IDBP-474170
human immunodeficiency virus type I enhancer binding protein 1
IDBP-480516
human immunodeficiency virus type I enhancer binding protein 1
IDBP-588127
human immunodeficiency virus type I enhancer binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:12008762-12164999
Strand Forward strand
Band p24.1
Transcripts
ENST00000379388 ENSP00000368698
ENST00000399469 ENSP00000382395
ENST00000442081 ENSP00000409078
ENST00000491710 ENSP00000419762
ENST00000487103 ENSP00000417348
ENST00000478545 ENSP00000418021
ENST00000484210 ENSP00000419721
ENST00000541134 ENSP00000445617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021366
View Gene Order
ENSBTAG00000001252
Not yet available
Cross-References
SwissProt
TrEMBL C9JLG1
UniProt Splice Variant
Entrez Gene 3096
UniGene Hs.567284
RefSeq NM_002114 XM_005249042
HUGO HGNC:4920
OMIM 194540
CCDS CCDS43426
HPRD 01925
IMGT
EMBL AL137221 AL157373 AL391828 Z98050
GenPept
RNA Seq Atlas 3096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca