InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIVEP1

Summary

InnateDB Protein

IDBP-61742.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIVEP1

Protein Name

human immunodeficiency virus type I enhancer binding protein 1

Synonyms

CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1; Schnurri-1; ZAS1; ZNF40; ZNF40A;

Species

Homo sapiens

Ensembl Protein

ENSP00000368698

InnateDB Gene

IDBG-61740 (HIVEP1)

Protein Structure

UniProt Annotation

Function

This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Cytoplasm. Nucleus.Isoform 3: Cytoplasm {ECO:0000269Ref.2}. Nucleus {ECO:0000269Ref.2}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated