InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FTCD

Summary

InnateDB Gene

IDBG-6187.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FTCD

Gene Name

formiminotransferase cyclodeaminase

Synonyms

LCHC1

Species

Homo sapiens

Ensembl Gene

ENSG00000160282

Encoded Proteins

IDBP-6189

formiminotransferase cyclodeaminase

IDBP-6191

formiminotransferase cyclodeaminase

IDBP-234650

formiminotransferase cyclodeaminase

IDBP-234652

formiminotransferase cyclodeaminase

IDBP-234654

formiminotransferase cyclodeaminase

IDBP-371459

formiminotransferase cyclodeaminase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:46136262-46155643

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000291670	ENSP00000291670
ENST00000355384	ENSP00000347545
ENST00000397748	ENSP00000380856
ENST00000397746	ENSP00000380854
ENST00000397743	ENSP00000380851
ENST00000446405	ENSP00000409015
ENST00000498355
ENST00000460011
ENST00000483568
ENST00000494498
ENST00000488577
ENST00000480950
ENST00000469240

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005542	folic acid binding
GO:0016740	transferase activity
GO:0030409	glutamate formimidoyltransferase activity
GO:0030412	formimidoyltetrahydrofolate cyclodeaminase activity

Biological Process

GO:0006548	histidine catabolic process
GO:0006760	folic acid-containing compound metabolic process
GO:0007010	cytoskeleton organization
GO:0008152	metabolic process
GO:0019556	histidine catabolic process to glutamate and formamide
GO:0019557	histidine catabolic process to glutamate and formate
GO:0034641	cellular nitrogen compound metabolic process
GO:0035999	tetrahydrofolate interconversion
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005814	centriole
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001155

View Gene Order

ENSBTAG00000020404

Not yet available

Pathways

NETPATH

REACTOME

REACT_1249

Histidine catabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00670

One carbon pool by folate pathway

hsa00340

Histidine metabolism pathway

INOH

INOH website

Folate metabolism pathway

INOH website

Histidine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.415846

RefSeq

NM_006657 NM_206965 XM_006723960

HUGO

OMIM

CCDS

CCDS13731

HPRD

08430

IMGT

EMBL

GenPept

RNA Seq Atlas