InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P2RY1

Summary

InnateDB Gene

IDBG-61871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY1

Gene Name

purinergic receptor P2Y, G-protein coupled, 1

Synonyms

P2Y1

Species

Homo sapiens

Ensembl Gene

ENSG00000169860

Encoded Proteins

IDBP-61873

purinergic receptor P2Y, G-protein coupled, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:152834693-152838051

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000305097

ENSP00000304767

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0031686	A1 adenosine receptor binding
GO:0043531	ADP binding
GO:0045028	G-protein coupled purinergic nucleotide receptor activity
GO:0045031	ATP-activated nucleotide receptor activity
GO:0045032	ADP-activated nucleotide receptor activity
GO:0046982	protein heterodimerization activity
GO:0097110	scaffold protein binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001973	adenosine receptor signaling pathway
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007568	aging
GO:0007596	blood coagulation
GO:0009612	response to mechanical stimulus
GO:0010469	regulation of receptor activity
GO:0010700	negative regulation of norepinephrine secretion
GO:0019233	sensory perception of pain
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030168	platelet activation
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0042060	wound healing
GO:0042312	regulation of vasodilation
GO:0042755	eating behavior
GO:0043270	positive regulation of ion transport
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046887	positive regulation of hormone secretion
GO:0051100	negative regulation of binding
GO:0060406	positive regulation of penile erection
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070848	response to growth factor
GO:0072659	protein localization to plasma membrane
GO:0090075	relaxation of muscle

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0044297	cell body
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density