InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RY1

Summary

InnateDB Protein

IDBP-61873.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY1

Protein Name

purinergic receptor P2Y, G-protein coupled, 1

Synonyms

P2Y1;

Species

Homo sapiens

Ensembl Protein

ENSP00000304767

InnateDB Gene

IDBG-61871 (P2RY1)

Protein Structure

UniProt Annotation

Function

Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. {ECO:0000269PubMed:9442040}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0031686	A1 adenosine receptor binding
GO:0043531	ADP binding
GO:0045028	G-protein coupled purinergic nucleotide receptor activity
GO:0045031	ATP-activated nucleotide receptor activity
GO:0045032	ADP-activated nucleotide receptor activity
GO:0046982	protein heterodimerization activity
GO:0097110	scaffold protein binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001973	adenosine receptor signaling pathway
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007568	aging
GO:0007596	blood coagulation
GO:0009612	response to mechanical stimulus
GO:0010469	regulation of receptor activity
GO:0010700	negative regulation of norepinephrine secretion
GO:0019233	sensory perception of pain
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030168	platelet activation
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0042060	wound healing
GO:0042312	regulation of vasodilation
GO:0042755	eating behavior
GO:0043270	positive regulation of ion transport
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046887	positive regulation of hormone secretion
GO:0051100	negative regulation of binding
GO:0060406	positive regulation of penile erection
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070848	response to growth factor
GO:0072659	protein localization to plasma membrane
GO:0090075	relaxation of muscle

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0044297	cell body
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density