Homo sapiens Gene: PLCB2
Summary
InnateDB Gene IDBG-6204.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PLCB2
Gene Name phospholipase C, beta 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137841
Encoded Proteins
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
Protein Structure
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40570377-40600136
Strand Reverse strand
Band q15.1
Transcripts
ENST00000260402 ENSP00000260402
ENST00000456256 ENSP00000411991
ENST00000560009
ENST00000559671 ENSP00000452916
ENST00000559381
ENST00000559618 ENSP00000454025
ENST00000558588 ENSP00000452642
ENST00000557821 ENSP00000453975
ENST00000558505
ENST00000560701
ENST00000561378
ENST00000558409
ENST00000560093
ENST00000543785 ENSP00000444652
ENST00000559634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008081 phosphoric diester hydrolase activity
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0050913 sensory perception of bitter taste
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031680 G-protein beta/gamma-subunit complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (q) signalling events pathway
G beta:gamma signalling through PLC beta pathway
PLC beta mediated events pathway
Presynaptic function of Kainate receptors pathway
Regulation of Insulin Secretion by Acetylcholine pathway
Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1) pathway
KEGG
African trypanosomiasis pathway
Carbohydrate digestion and absorption pathway
Gastric acid secretion pathway
Amoebiasis pathway
Chagas disease (American trypanosomiasis) pathway
Pancreatic secretion pathway
Salivary secretion pathway
Metabolic pathways pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Huntington`s disease pathway
GnRH signaling pathway pathway
Gap junction pathway
Wnt signaling pathway pathway
Inositol phosphate metabolism pathway
Long-term potentiation pathway
Alzheimer`s disease pathway
Phosphatidylinositol signaling system pathway
Taste transduction pathway
Long-term depression pathway
Calcium signaling pathway pathway
Melanogenesis pathway
INOH
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
Inositol phosphate metabolism pathway
GPCR signaling pathway
PID BIOCARTA
PID NCI
RAC1 signaling pathway
PAR4-mediated thrombin signaling events
Alpha-synuclein signaling
Thromboxane A2 receptor signaling
S1P1 pathway
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling events
Cross-References
SwissProt Q00722
TrEMBL B9EGH5 H0YK35 H0YNI4 Q59F77 Q9BVT6
UniProt Splice Variant
Entrez Gene 5330
UniGene Hs.355888
RefSeq NM_004573
HUGO 9055
OMIM 604114
CCDS CCDS42020
HPRD 04985
IMGT
EMBL AB209583 AC020658 AK291657 BC000939 BC009009 BC136467 BT006905 CH471125 M95678
GenPept AAA36453 AAH00939 AAH09009 AAI36468 AAP35551 BAD92820 BAF84346 EAW92402
ImmGen PLCB2 (murine)
RNA Seq Atlas 5330