Homo sapiens Gene: PLCB2

Summary
InnateDB Gene IDBG-6204.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PLCB2
Gene Name phospholipase C, beta 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137841
Encoded Proteins
IDBP-6206 phospholipase C, beta 2
IDBP-365941 phospholipase C, beta 2
IDBP-589651 phospholipase C, beta 2
IDBP-597506 phospholipase C, beta 2
IDBP-602652 phospholipase C, beta 2
IDBP-596760 phospholipase C, beta 2
IDBP-586064 phospholipase C, beta 2
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15: 40570377-40600136
Strand Reverse strand
Band q15.1
Transcripts
ENST00000260402  ENSP00000260402
ENST00000456256  ENSP00000411991
ENST00000560009 
ENST00000559671  ENSP00000452916
ENST00000559381 
ENST00000559618  ENSP00000454025
ENST00000558588  ENSP00000452642
ENST00000557821  ENSP00000453975
ENST00000558505 
ENST00000560701 
ENST00000561378 
ENST00000558409 
ENST00000560093 
ENST00000543785  ENSP00000444652
ENST00000559634 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein‑Protein  11
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 6 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008081 phosphoric diester hydrolase activity
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0050913 sensory perception of bitter taste
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031680 G-protein beta/gamma-subunit complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000040061 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000019079 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_18283 G alpha (q) signalling events
REACT_19145 G beta:gamma signalling through PLC beta
REACT_15426 PLC beta mediated events
REACT_21254 Presynaptic function of Kainate receptors
REACT_18405 Regulation of Insulin Secretion by Acetylcholine
REACT_19193 Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)
KEGG
hsa05143  African trypanosomiasis
hsa05010  Alzheimer`s disease
hsa05146  Amoebiasis
hsa04020  Calcium signaling pathway
hsa04973  Carbohydrate digestion and absorption
hsa05142  Chagas disease (American trypanosomiasis)
hsa04062  Chemokine signaling pathway
hsa04540  Gap junction
hsa04971  Gastric acid secretion
hsa04912  GnRH signaling pathway
hsa05016  Huntington`s disease
hsa00562  Inositol phosphate metabolism
hsa04730  Long-term depression
hsa04720  Long-term potentiation
hsa04916  Melanogenesis
hsa01100  Metabolic pathways
hsa04972  Pancreatic secretion
hsa04070  Phosphatidylinositol signaling system
hsa04970  Salivary secretion
hsa04742  Taste transduction
hsa04270  Vascular smooth muscle contraction
hsa04310  Wnt signaling pathway
INOH
INOH website Heterotrimeric GPCR signaling pathway (through G alpha q, PLC beta and ERK cascade) - GPCR signaling (G alpha q)
INOH website Heterotrimeric GPCR signaling pathway (through glutamate, G alpha q and PLC beta) - GPCR GroupI metabotropic glutamate receptor signaling pathway
INOH website Inositol phosphate metabolism
INOH website PLC beta signaling - GPCR GroupI metabotropic glutamate receptor signaling pathway
INOH website PLC beta signaling - GPCR signaling (G alpha q)
PID BIOCARTA
PID NCI
alphasynuclein_pathway Alpha-synuclein signaling
il8cxcr1_pathway IL8- and CXCR1-mediated signaling events
il8cxcr2_pathway IL8- and CXCR2-mediated signaling events
thrombin_par4_pathway PAR4-mediated thrombin signaling events
rac1_pathway RAC1 signaling pathway
s1p_s1p1_pathway S1P1 pathway
txa2pathway Thromboxane A2 receptor signaling
Cross-References
SwissProt Q00722 
TrEMBL B9EGH5 H0YK35 H0YNI4 Q59F77 Q9BVT6
UniProt Splice Variant
Entrez Gene 5330 
UniGene Hs.355888
RefSeq NM_004573 
HUGO 9055 
OMIM 604114
CCDS CCDS42020 
HPRD 04985
IMGT
EMBL AB209583 AC020658 AK291657 BC000939 BC009009 BC136467 BT006905 CH471125 M95678
GenPept AAA36453  AAH00939  AAH09009  AAI36468  AAP35551  BAD92820  BAF84346  EAW92402 
ImmGen PLCB2 (murine) 
RNA Seq Atlas 5330