Homo sapiens Gene: PLCB2
Summary
InnateDB Gene IDBG-6204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCB2
Gene Name phospholipase C, beta 2
Synonyms PLC-beta-2;
Species Homo sapiens
Ensembl Gene ENSG00000137841
Encoded Proteins
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
phospholipase C, beta 2
Protein Structure
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40278176-40307935
Strand Reverse strand
Band q15.1
Transcripts
ENST00000260402 ENSP00000260402
ENST00000456256 ENSP00000411991
ENST00000560009
ENST00000559671 ENSP00000452916
ENST00000559381
ENST00000559618 ENSP00000454025
ENST00000558588
ENST00000557821 ENSP00000453975
ENST00000558505
ENST00000560701
ENST00000561378
ENST00000558409
ENST00000560093
ENST00000543785 ENSP00000444652
ENST00000559634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0050913 sensory perception of bitter taste
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Presynaptic function of Kainate receptors pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
PLC beta mediated events pathway
G-protein beta:gamma signalling pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
Opioid Signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Acetylcholine regulates insulin secretion pathway
G-protein mediated events pathway
Activation of Kainate Receptors upon glutamate binding pathway
Free fatty acids regulate insulin secretion pathway
Transmission across Chemical Synapses pathway
G beta:gamma signalling through PLC beta pathway
Inositol phosphate metabolism pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
Inositol phosphate metabolism pathway
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
Gap junction pathway
Long-term potentiation pathway
Long-term depression pathway
Taste transduction pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Carbohydrate digestion and absorption pathway
Alzheimer's disease pathway
Huntington's disease pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
Amoebiasis pathway
INOH
GPCR signaling pathway
Inositol phosphate metabolism pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Alpha-synuclein signaling
Thromboxane A2 receptor signaling
S1P1 pathway
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling events
RAC1 signaling pathway
PAR4-mediated thrombin signaling events
Cross-References
SwissProt Q00722
TrEMBL H0YNI4 Q9BVT6
UniProt Splice Variant
Entrez Gene 5330
UniGene Hs.355888
RefSeq NM_001284297 NM_001284298 NM_001284299 NM_004573 XM_005254448 XM_005254450 XM_006720571
HUGO HGNC:9055
OMIM 604114
CCDS CCDS42020 CCDS61591 CCDS61592 CCDS73704
HPRD 04985
IMGT
EMBL AC020658 AK291657 BC000939 BC009009 BC136467 BT006905 CH471125 M95678
GenPept AAA36453 AAH00939 AAH09009 AAI36468 AAP35551 BAF84346 EAW92402
ImmGen PLCB2 (murine)
RNA Seq Atlas 5330